ASPiRATION

An observational cohort study to assess the clinical impact of comprehensive genomic profiling in metastatic lung cancer patients

Challenge

Lung cancer is the leading cause of cancer death in Australia and worldwide, with a five-year survival rate of only 17 per cent.

Study

The ASPiRATION program is a pioneering partnership between government, industry and academia. The study is led by TOGA, in collaboration with Omico (Australian Genomic Cancer Medicine Centre) and the NHMRC Clinical Trials Centre (CTC). The program is supported by funding from the federal government’s Medical Research Future Fund (MRFF) and Roche.

Impact

The ASPiRATION program is the first of its kind in Australia to generate high-quality, real-world data about the impact and value of comprehensive genomic profiling (CGP) in delivering precision medicine and personalised healthcare. Identifying actionable molecular targets through CGP provides patients with opportunities to receive novel targeted treatments via therapeutic substudies.

Progress

Molecular screening for ASPiRATION commenced in late 2020, with expansion to fifteen participating hospitals throughout Australia planned by mid 2021. The first therapeutic substudy has commenced, four more substudies are nearing activation, and development is ongoing to bring more therapeutic substudies online this year.

Find an open ASPiRATION site

Find an open ASPiRATION substudy site

Information and forms

Referral form

Information sheet for clinicians

General information sheet

Contacts

For further information, contact most@garvan.org.au

For progress on ethics. governance and study start up at particular sites, contact the NHMRC Clinical Trial Centre via most@ctc.usyd.edu.au