Clinical Trials

18/001 DREAM3R

DREAM3R – DuRvalumab (MEDI4736) with chEmotherapy as first line treAtment in advanced pleural Mesothelioma – A phase 3 Randomised trial

Recruitment target:
480
Status:
In Follow-up
(Recruitment closed early at 214 participants due to poor accrual)

Summary:

DREAM3R is determining the effectiveness of adding immunotherapy to standard first line chemotherapy with cisplatin and pemetrexed in advanced malignant pleural mesothelioma and identifying potential and prognostic biomarkers from blood and tissue. Durvalumab is a type of immunotherapy that works by blocking a body substance called Programmed Death-Ligand 1 (PD-L1). Blocking PD-L1 helps the body’s immune system attack cancer cells.

Initially participants were randomised to durvalumab and chemotherapy or the control arm of chemotherapy alone. However, when the dual immunotherapy combination of ipilimumab and nivolumab became standard of care, DREAM3R was amended so participants randomised to the control arm could choose, in consultation with their treating clinician, the ipilimumab and nivolumab combination immunotherapy treatment or chemotherapy.

Clinical trial design:

Open-label Phase III randomised clinical trial

Indication:

Newly diagnosed unresectable malignant pleural mesothelioma

Intervention:

First-line treatment with standard chemotherapy of pemetrexed and cisplatin. Two-thirds of the participants in the study will be randomly assigned to also receive durvalumab (immunotherapy).

More information:

For patients

For clinicians

This study is a collaboration with PrECOG in the USA.

Contact: dream3r.study@sydney.edu.au

 

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