NITRO clinical trial information
Dataset Name: A Phase III, randomised trial of adding nitroglycerin to first line chemotherapy for advanced non-small cell lung cancer
Author: Prof Andrew Davidson, Royal Perth Hospital
Publisher: Thoracic Oncology Group Australasia
Funding: Cancer Council WA, Cancer Council QLD, Cancer Council NSW, National Health and Medical Research Council.
Date made available: 2023
Dataset: Individual participant data
Patient sample size: 372
Dataset description: Patients starting one of five, prespecified, platinum-based doublets as first-line chemotherapy for advanced NSCLC were randomly allocated treatment with or without nitroglycerin 25 mg patches for 2 days before, the day of, and 2 days after, each chemotherapy infusion. Progression-free survival (PFS) was the primary end point. Accrual was stopped after the first interim analysis of 270 events. Chemotherapy was predominantly with carboplatin and gemcitabine (79%) or carboplatin and paclitaxel (18%). The final analysis included 345 events in 372 participants with a median follow-up of 33 months.
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