Clinical Trials

PRIME-Lung

Primary Radiotherapy In Metastatic Lung Cancer (PRIME-Lung)

Recruitment target:

420

Status:

In Start-up

Summary:

The primary aim of this clinical trial is to evaluate whether radiotherapy delivered prior to standard treatment improves overall survival in patients with metastatic non-small cell lung cancer (NSCLC). The hypothesis is that early, highly targeted radiotherapy may reduce the risk of further metastatic spread, thereby improving survival outcomes. Similar interventions have shown event-free survival benefits in lung, prostate, and nasopharyngeal cancer trials.

The trial builds on PRIME-Lung-pilot with 40 patients, which demonstrated that the intervention is safe and well-tolerated. Based on these findings, the trial will now expand to include more sites and a larger patient cohort.

Clinical trial design:

Phase II open label two arm randomised controlled clinical trial.

Indication:

Newly diagnosed metastatic NSCLC.

Intervention:

Radiotherapy prior to standard of care treatment.

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